The Fibroblast of the Relationship Between FGFR2 Gene Rs2981582 Polymorphism and Breast Cancer Risk

Background and Aim: Breast cancer is the most common type leading cause of cancer-induced deaths in women, worldwide. The Fibroblast Growth Factor Receptor 2 (FGFR2) a tyrosine kinase receptor that plays an essential role growth, invasion, movement, angiogenesis tumor cells. Several single nucleotide polymorphisms have been found intron FGFR2 gene, i.e., associated with high risk breast cancer. Genetic variation this new factor for current study aimed to evaluate association single-nucleotide polymorphism rs2981582C/T women Methods & Materials: In total, 80 healthy (controls) were selected from Markazi Province, Iran participate research. Polymorphism rs2981582 was analyzed investigate its DNA extraction blood samples performed using kit. presence these determined by Polymerase Chain Reaction-Restriction Fragment Length (PCR - RFLP). Statistical analyses SPSS Chi-squared test at P≤0.05. Ethical Considerations: This approved Ethics Committee Arak University (Code: IR.ARAKMU.REC.1395.28). Results: Significant differences observed frequency gene between control patient groups (P=0.000). group, TT genotype significantly (P=0.001; OR=3.566). On other hand, allele C indicated protective against disease Conclusion: obtained data revealed significant relationship C/T cancer; thus, could be used as biomarker predict